We have started to test telomerase gene therapy to rejuvenate microglial cells in a Alzheimer’s disease human study, building on promising research study data.There is mounting evidence to indicate that telomerase plays an active role in protection from Tau Pathology. Various experiments have encouraged us to pursue this therapy with the goal of eliminating the suffering this disease brings.
Integrated Health System’s gene therapy targeting neurodegeneration utilizes an adeno-associated virus (AAV) vector platform modified for the enhanced delivery to neural tissue. The genes to treat the disorder are inserted into the delivery method, which then delivers the genes of interest to the patient’s cells. In recent years, AAV gene therapies have been tested in humans with great success, and no evidence of adverse effects has been visible. There are numerous clinical trials currently being conducted with AAV gene therapy for many diseases.
A Research Review: Neurodegeneration and Telomerase
Critically short telomeres lead to oxidative stress and neuroinflammation – established contributors to Alzheimer’s pathology.
The TERT protein appears to reduce toxic tau tangle accumulation and alleviate mitochondrial stress.
Senescent microglial cells are linked to Alzheimer’s. Telomerase activation can prevent cellular senescence by repairing critically short telomeres.
Aggregated amyloid beta and Alzheimer’s pathology inhibit telomerase expression; accelerating disease progression by accelerating microglial senescence.
Immune cell senescence is associated with Alzheimer’s onset.
Astrocyte senescence is also correlated with Alzheimer’s onset and may be prevented by telomerase induction.
Old microglia exposed to the conditioned media of young microglia are better able to reduce amyloid plaque formation.
Our technology and care, your healthy longevity:
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