We have started to test telomerase gene therapy to rejuvenate microglial cells in a Alzheimer’s disease human study, building on promising research study data.There is mounting evidence to indicate that telomerase plays an active role in protection from Tau Pathology. Various experiments have encouraged us to pursue this therapy with the goal of eliminating the suffering this disease brings.
Integrated Health System’s gene therapy targeting neurodegeneration utilizes an adeno-associated virus (AAV) vector platform modified for the enhanced delivery to neural tissue. The genes to treat the disorder are inserted into the delivery method, which then delivers the genes of interest to the patient’s cells. In recent years, AAV gene therapies have been tested in humans with great success, and no evidence of adverse effects has been visible. There are numerous clinical trials currently being conducted with AAV gene therapy for many diseases.
A Research Review: Neurodegeneration and Telomerase
Critically short telomeres lead to oxidative stress and neuroinflammation – established contributors to Alzheimer’s pathology.
The TERT protein appears to reduce toxic tau tangle accumulation and alleviate mitochondrial stress.
Senescent microglial cells are linked to Alzheimer’s. Telomerase activation can prevent cellular senescence by repairing critically short telomeres.
Aggregated amyloid beta and Alzheimer’s pathology inhibit telomerase expression; accelerating disease progression by accelerating microglial senescence.
Immune cell senescence is associated with Alzheimer’s onset.
Astrocyte senescence is also correlated with Alzheimer’s onset and may be prevented by telomerase induction.
Old microglia exposed to the conditioned media of young microglia are better able to reduce amyloid plaque formation.
Meet our doctor: Dr. Jason Williams, MD
Dr Williams CMO is a radiologist. He obtained his medical degree from Louisiana State University and has also completed an internship in Internal Medicine at The University of South Alabama. He is passionate about gene and cellular therapies, administered under image guidance. Image guided cancer therapies are also one of his interests. For several years, he did research with adenoviral vector technology used to treat cancer. He was selected for the RSNA Research Fellow Award. He has completed training in image guided cancer and spine procedures, and is board certified by the American Board of Radiology. He has research interests in gene therapy and stem cell reprogramming, as well as using CT and MRI for minimally invasive procedures related to the spine and cancer.
Our technology and care, your healthy longevity:
IHS, in partnership with BioViva, is dedicated to providing you with the latest breakthroughs in medical technologies to help you at this difficult time in your life. Our doctors are here to help you every step of the way. To schedule your 20 minutes consultation with a doctor from Integrated Health Systems, please click
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