Partner With Us

Integrated Health Systems wants to partner with your practice. We are interested in clinics specializing in regenerative, sports, and anti-aging medicine. We offer several gene therapies meant to systematically address an array of health issues by tackling the aging process itself at its root cause.

Regenerative and Anti-Aging Medicine

Telomeres are one of the hottest topics in aging research right now, and for good reason. Our telomerase gene therapy can restore telomere length. Follistatin, a myostatin inhibitor, fights sarcopenia – one of the major contributors of age-related frailty and Metabolic Syndrome.

In scientific studies telomerase has been reported to have a positive effect on overall health and fitness, including but not limited to “insulin sensitivity, osteoporosis, neuromuscular coordination and several molecular biomarkers of aging. ”
Geneticist Richard Cawthon and his colleagues at the University of Utah discovered that in people over 60, those with shorter telomeres were three times more likely to die from heart disease and eight times more likely to die from infectious diseases.
Our first patient to receive a telomerase activating gene therapy saw her telomeres de-age by 33 years.
Sarcopenia contributes to frailty. Approximately 7% of people over 65 years are dangerously frail – rising to over 45% in the over 85 demographic. Follistatin gene therapy can fight sarcopenia.
Tested with success in Duchenne’s muscular dystrophy patients, follistatin encourages muscle growth even in sedentary people by inhibiting myostatin.
The loss of muscle mass contributes to Metabolic Syndrome, which predisposes you to diabetes and heart disease. Muscle mass is critical to your health.

Sports Medicine

Even the most active of people begin losing muscle mass as they grow older and that’s why follistatin has obvious benefits for physically active people, from professional athletes to casual fitness enthusiasts looking to stay in shape through their golden years. The most exercise can do is slow sarcopenia down.

Our eighth patient states, “I can feel my muscles are stronger and recover faster after exercise. I also like that my scans show that they are less fatty than before treatment.”

Telomerase, as mentioned before, has a positive effect on bone strength. Klotho is more strongly correlated to IQ than any known gene. Telomerase also has a beneficial effect on motor function and cognitive performance. Both of these are essential to success on and off the field.

Anything that shaves off recovery time, helps burn fat, and improve muscle strength, has obvious and far-reaching applications in athletics.

Cosmetics

Beauty comes from the inside. We believe this is true because there’s compelling evidence for it. That’s why cosmetic surgeons may be intrigued by the potential of follistatin and telomerase gene therapies.

Besides helping people feel better, telomerase and follistatin can help them look better too. In 2005 Flores, Blasco, and Cayuela linked telomerase activation to the mobilization of stem cells. Skin cells treated with telomerase reverse transcriptase replicated 40 more times than the control groups and exhibited more youthful gene expression profiles.

Disease Specific Treatments

Telomerase shows promise as a treatment for neurodegenerative diseases like Alzheimer’s and Parkinson’s disease by modulating microglia function
Klotho (or the lack thereof) is an important determinant in the development and progression of Chronic Kidney Disease
Follistatin combats Metabolic Syndrome, slew of related issues including high blood pressure, high blood sugar, excess body fat around the waist, and abnormal cholesterol or triglyceride levels.
The greatest killers in the developed world are largely caused by one factor, aging. By targeting the underlying processes of aging we can prevent, ameliorate, and perhaps even reverse, some of its unwanted effects.

For further information about our treatments and associated service fees, please contact us at info@integrated-health-systems.com

References and Further Reading

Blasco, Maria A. “Telomeres and human disease: ageing, cancer and beyond.” Nature Reviews Genetics 6.8 (2005): 611.

Boukamp, Petra. “Skin aging: a role for telomerase and telomere dynamics?.” Current molecular medicine 5.2 (2005): 171-177.

Cameron, Brent, and Gary E. Landreth. “Inflammation, microglia, and Alzheimer’s disease.” Neurobiology of disease 37.3 (2010): 503-509.

Cawthon, Richard M., et al. “Association between telomere length in blood and mortality in people aged 60 years or older.” The Lancet 361.9355 (2003): 393-395.

Cawthon, Richard. “Methods of predicting mortality risk by determining telomere length.” U.S. Patent No. 9,169,516. 27 Oct. 2015.

Dubal, Dena B., et al. “Life extension factor klotho enhances cognition.” Cell reports 7.4 (2014): 1065-1076.

Flores, Ignacio, María L. Cayuela, and María A. Blasco. “Effects of telomerase and telomere length on epidermal stem cell behavior.” Science 309.5738 (2005): 1253-1256.

Hu, Ming Chang, Makoto Kuro-o, and Orson W. Moe. “Klotho and chronic kidney disease.” Phosphate and Vitamin D in Chronic Kidney Disease. Vol. 180. Karger Publishers, 2013. 47-63.

Kim, Ji-Hee, et al. “Biological role of anti-aging protein Klotho.” Journal of lifestyle medicine 5.1 (2015): 1.

Kim, Tae Nyun, et al. “Skeletal muscle mass to visceral fat area ratio is associated with metabolic syndrome and arterial stiffness: the Korean Sarcopenic Obesity Study (KSOS).” Diabetes research and clinical practice 93.2 (2011): 285-291.

Morley, John E., et al. “Sarcopenia.” Journal of Laboratory and Clinical Medicine 137.4 (2001): 231-243.